This paper summarizes studies for phase clinical trials . it mainly introduces different , methods about determining maximum tolerated dose ( mtd ) and proposes further subjects for future research 摘要本文综述关于期临床试验的研究。主要介绍确定最大耐受剂量( mtd )的不同方法,以及提出可以进一步进行研究的问题。
Maximum tolerated dose (MTD) refers to the highest dose of a radiological or pharmacological treatment that will produce the desired effect without unacceptable toxicity. The purpose of administering MTD is to determine whether long-term exposure to a chemical might lead to unacceptable adverse health effects in a population, when the level of exposure is not sufficient to cause premature mortality due to short-term toxic effects.
maximum tolerated doseとは意味:最大耐量{さいだい たいりょう} maximum tolerated dose meaning:[Medicine] The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology,1st...